“trimethoprim”的英文意思_释义_用法

单词

trimethoprim

释义

trimethoprim Pharm.|traɪˈmɛθəʊprɪm|
[f. trimethyl + oxy- + pyrimidine, constituent parts of the systematic name (see quot. 1962).]
An antibiotic, C₁₄H₁₈N₄O₃, that is usually given in conjunction with a sulphonamide, esp. in the treatment of malaria and of respiratory and urinary infections.
1962Jrnl. Medicinal & Pharmaceutical Chem. V. 1107 Compound LXV, 2,4-diamino-5-(trimethoxybenzyl)-pyrimidine (B.W. 56–72, trimethoprim), has been selected for detailed study and clinical trial.1968New Scientist 17 Oct. 147/1 A tablet of Septrin actually contains two drugs, one old—a sulphonamide—and one ‘new’—trimethoprim.1974R. M. Kirk et al. Surgery ii. 29/1 Trimethoprim acts synergistically with sulphonamides, since they interfere sequentially at two stages in bacterial synthesis of folic acid.1977Lancet 2 July 4/1 Much of the shigellosis could be successfully treated with ampicillin trihydrate and closely related antibiotics, or with cotrimoxazole (trimethoprim and sulphamethoxazole).

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