| 单词 |
protriptyline |
| 释义 |
protriptyline Pharm.|prəʊˈtrɪptɪliːn|
Also (erron.) protryptiline, protryptyline.
[f. propyl + tri- + he)ptyl (s.v. heptane) + -ine5.]
A tricyclic antidepressant, 5-(3-methylaminopropyl)dibenzo[a, e] cycloheptatriene, C19H21N, given as the hydrochloride, a white bitter-tasting powder.
1963Amer. Jrnl. Psychiatry CXX. 594/1 In an attempt to evaluate a derivative of amitriptyline, MK-240 (protryptyline), where the ‘sleepiness’ was removed by a change in the chemical formula, the drug was studied in 61 patients with various types of depression. 1965Psychosomatics VI. 346/1 Protriptyline is at least five times as active as amitriptyline against depressive reactions. 1966Canad. Med. Assoc. Jrnl. XCIV. 1220/1 Protryptiline gave chemical results that compared favourably with those of antidepressants of established value. 1978Nature 23 Mar. 330/1 The tricyclic anti⁓depressant drugs which are tertiary amines..were more potent inhibitors than those which are secondary amines (desmethylimipramine, nortriptyline, protriptyline). |
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