| 单词 |
probenecid |
| 释义 |
probenecid Pharm.|prəʊˈbɛnɪsɪd|
[f. propyl + benzoic a. + -e- + acid a. and n.]
A white, crystalline, bitter-tasting powder which is a uricosuric agent used esp. to treat gout; p-(di-n-propylsulphamoyl)benzoic acid, (C3H7)2NSO2·C6H4COOH.
1950Ann. Internal Med. XXXIII. 18 Benemid. [Note] Sharp and Dohme's trademark for p-(di-n-propylsulfamyl)-benzoic acid. This drug has been tentatively given the generic designation ‘probenecid’. 1953Proc. Soc. Exper. Biol. & Med. LXXXII. 604/1 Probenecid has been shown to inhibit reversibly the renal tubular secretion of a number of organic acids, such as penicillin.., phenolsulfonphthalein.., and para-aminohippuric acid. 1963Lancet 5 Jan. 54/2 People with these vague aches associated with uric-acid blood-level elevation have responded well to colchicine intravenously as initial treatment and probenecid daily. 1974A. Henry in R. M. Kirk et al. Surgery xv. 305 Acute attacks [of gout] are controlled by colchicine or phenylbutazone, while urico⁓suric agents such as probenecid keep the plasma uric level down and must be continued throughout life. |
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