“hypermutation”的英文意思_释义_用法

单词

hypermutation

释义

hypermutation, n. Genetics.
Brit. |ˌhʌɪpəmjuːˈteɪʃn|, U.S. |ˈˌhaɪpərˌmjuˈteɪʃ(ə)n|
[‹ hyper- prefix + mutation n. With sense 2 compare slightly earlier hypermutability n.]
1. A mutation resulting in a major phenotypic change. rare. disused.
1934W. H. Manwaring in Science 25 May 468/2 Similar hyper-mutations are known to occur during the course of natural clinical infections.
2. Mutation occurring at a high rate; frequent mutation; a form resulting from such mutation.
1966Proc. Royal Soc. (B.)166133 Multiple structural differences could arise from a variety of mechanisms, for example, an accumulation of point mutations, hypermutation, somatic chromosomal rearrangements, [etc.].1977Science 29 July 450/2 [This] would in turn lead to a hypermutation-induced expansion of the antibody repertoire.1996Economist 16 Nov. 140/2 Work on captive laboratory bacteria has generally found that hypermutation is rare, as the conventional wisdom would suggest.2003Blood1014047 The base pair substitutions within the rearranged V(H) genes represent hypermutations.

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