| 单词 |
fludrocortisone |
| 释义 |
fludrocortisone Pharm.|ˌfluːdrəʊˈkɔːtɪzəʊn|
[f. *flu(orohy)drocortisone.]
A synthetic derivative (C21H29FO5) of hydrocortisone which causes retention of sodium and loss of potassium and which is given orally in the treatment of adrenocortical deficiency and to supplement cortisone in the treatment of Addison's disease; also ellipt. for the acetate, the form in which the drug is usu. given.
1958Clin. Sci. XVII. 205 These compounds differed from hydrocortisone only by the presence of an additional halogen atom, and fludrocortisone (9α-fluorohydrocortisone acetate) has proved to be the most active of the series. 1961Lancet 25 Mar. 632/1 In the adrenalectomised subjects, aldosterone by mouth had 1/25th to 1/30th the potency of fludrocortisone in the maintenance of sodium balance. 1965Goodman & Gilman Pharmacol. Basis Therapeutics (ed. 3) lxxii. 1633 Fludrocortisone acetate..is the most potent synthetic mineralocorticoid. 1969R. George in J. A. Bevan Essent. Pharmacol. xxxiv. 361 Fludrocortisone is used extensively as an anti-inflammatory agent but only in topical preparations. |
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