“amphotericin”的英文意思_释义_用法

单词

amphotericin

释义

amphotericin, n. Pharm.|æmfəˈtɛrɪsɪn|
[f. amphoteric a. + -in¹.]
Either of two amphoteric polyenes with antifungal properties obtained from the soil bacterium Streptomyces nodosus; esp. the antibiotic C₄₇H₇₃NO₁₇ (more fully amphotericin B), used to treat some serious fungal infections.
1956J. Vandeputte et al. in Antibiotics Ann. 1955–6 587 A Streptomyces species (M4575) has been found to produce two antifungal agents that we have named amphotericins A and B.1964S. Duke-Elder Parsons' Dis. Eye (ed. 14) xiv. 144 Many fungi are sensitive to nystatin, amphotericin or trichomycin.1977Ann. Internal Med. LXXXVI. 47/1 Amphotericin B is a polyene antifungal antibiotic that binds to cholesterol in the plasma membrane of eukaryotic cells.1989Lancet 3 June 1262/1 Because of the deleterious effects of amphotericin B on renal transplants, he was started on fluconazole 200 mg orally every second day.

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