| Acronym | Definition |
|---|
| UPI | United Press International |
| UPI | Universitas Pendidikan Indonesia (Indonesian: Indonesia University of Education) |
| UPI | University Physicians Inc. |
| UPI | Universal Pictures International (film) |
| UPI | Unpaid Item (eBay) |
| UPI | Unione Delle Province d'Italia (Union of the Province of Italy; benevolent group) |
| UPI | Ulead Photo Impact |
| UPI | Url Programming Interface |
| UPI | Upper Prediction Interval |
| UPI | Unpaid Item |
| UPI | Ulead Color Picker |
| UPI | Util Pocket Interface |
| UPI | User Programmable Interface |
| UPI | Universal Peripheral Interface |
| UPI | Unique Project Identifier |
| UPI | Ulkopoliittinen Instituutti (Finnish Institute of International Affairs, Helsinki, Finland) |
| UPI | User Program Interface |
| UPI | Universal Personal Identification |
| UPI | Uteroplacental Insufficiency (pregnancy risk factor) |
| UPI | Unique Patient Identifiers (HIPAA) |
| UPI | Utilities, Power, and Infrastructure |
| UPI | Unión Profesional Informática |
| UPI | Unidentified Party Injury |
| UPI | User Payload Identifier |
| UPI | Unione Popolare Italiana (Italian: Italian Popular Union) |
| UPI | Unocal Philippines, Inc (formerly Philippine Geothermal, Inc) |
| UPI | Useless Piece of Information |
| UPI | Upper Plenum Injection |
| UPI | Union des Professions Immobilières de Belgique (French: Union of Real Estate Professionals in Belgium) |
| UPI | Universal Pensions Incorporated |