| PJFS | PJFT | PJG | PJGH | PJGT |
| Open Packet Telephony | Open Panel Discussion | Open Paraesophageal Hernia Repair | Open Parlor Night | Open Partial Nephrectomy |
| Open Participation Software | Open Participation Software for Java | Open Patent Alliance | Open Path Gas Detection | Open Payment Initiative |
| Open PC Server Integration | Open Peer Review | Open Peripheral Interface | Open Pgp | OPENPGP |
| Open Philanthropy Exchange | Open Philosophies for Associative Autopoietic Digital Ecosystems | Open Photography Forum | Open Pit Mining Association | Open Planar Array |
| Open Plan Maintenance Information System | Open Plan Office System | Open Platform Architecture | Open Platform for Cordless Applications | Open Platform for Emergency Networks |
| Open Platform for Network Functions Virtualization | Open Platform for Security | Open Platform Management Architecture | Open Plug-In Technology | Open-Plus-Closed-Loop |
| Open Pollinated Variety | Open Portal Systems | Open POSIX (Portable Operating System Interface for Unix) Test Suite | Open Postscript Interface | Open Prepress Interface |
| Open Presence Network | Open Problems in Topology | Open Process | Open Process Control | Open Process-Control Unified System |
| OPEN Process Framework | Open Product Key | Open Profiling Standard | Open Programming Language | Open Projects Network |
| Open Protocol Enhanced Network | Open Protocol Enhanced Networks | Open Protocol Technology | Open Proxy Connection | Open Proxy Monitor |
| Open Proxy Scanning Bot | Open Publication Distribution System | Open Publication License | Open Publication Structure | Open Public Hearing |
| Open Public License | Open Public Local Access Network | Open Public Meetings Act | Open Public Records Act | Open Public Service |
| Open Publishing Environment | Open Publishing Lab | Open Pulmonary Embolectomy | Open Purchase Order | Open Purchase Order Header |
| Open Purchase Order Line | Open Query System | Open Queuing Network | Open Quicktime | Open Rack Vaporizer |
| Open Radio Archive Network Group | Open Radio for North Korea | Open Ranks Inspection | Open Reading Frame | Open reading frame |
| Open Reading Frame 0 | Open Reading Frame 1 | Open Reading Frame 2 | Open Reading Frame 6 | Open Reading Frame A |
| open reading frame comprising 250 condons | Open Reading Frame of 129 Codons | open reading frame of 169 codons | Open Reading Frames 4 | Open Reading Frame Sequence |
| Open Reading Frame X | Open Realtime Kernel Interface Definition | Open Records Act | Open Records Request | Open Reduction and External Fixation |
| Open Reduction and Percutaneous Pinning | Open reduction internal fixation | Open Regional Dialogue on Internet Governance | Open Relay Behaviour-modification System | Open Relay Blackhole Zones |
| Open Relay Black List | Open Relay Database | Open Relay Data Base | Open, Reliable Communications Architecture | Open Repair |
| Open Reversible Inflatable Liferafts | Open Right Half Plane | Open Robot Controller Architecture | Open Robotics Peripheral Platform | Open Role Playing Game |
| Open Role-Playing System | Open Roll Over Protective Structure | Open Root | Open Root Server Confederation | Open Root Server Network |
| Open Router Project | Open Runtime Platform | Open Russian Electronic Library | Open Russian Film Festival | OPEN.SC |
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