| Acronym | Definition |
|---|
| MLE | Multilingual Education (literacy) |
| MLE | Maximum Likelihood Estimation |
| MLE | Multicultural London English (linguistics) |
| MLE | Medium to Large Enterprise |
| MLE | Maximum Likelihood Estimate |
| MLE | Managed Learning Environment |
| MLE | Mid-Level Exception (athletic contacts) |
| MLE | Material, Labor, Equipment (cost factors) |
| MLE | Mobile Link Entity |
| MLE | Mean Life Expectancy (statistic) |
| MLE | Moneyless Economy |
| MLE | Master of Land Economy (UK) |
| MLE | Magazine Lee Enfield (firearms) |
| MLE | Merrill Lynch Europe (investing) |
| MLE | Master of Applied Linguistics and Exegesis (degree; Canada) |
| MLE | Medical Laboratory Evaluation (Medical Laboratory Proficiency Testing Program, Washington, DC) |
| MLE | Mycobacterium Leprae |
| MLE | Multi-Lamellar Emulsion |
| MLE | Mesoscale Lightning Experiment |
| MLE | Modified Ludzack-Ettinger (process used for wastewater treatment) |
| MLE | MAGTF (Marine Air-Ground Task Force) Liaison Element |
| MLE | Male, Maldives - Male International (Airport Code) |
| MLE | Magical Law Enforcement (Harry Potter) |
| MLE | Midline Episiotomy (obstetrics) |
| MLE | Major League Equivalency (baseball statistic) |
| MLE | Molecular Layer Epitaxy |
| MLE | Multi-Level Effects |
| MLE | Marine Liaison Element |
| MLE | Mode of the Likelihood |
| MLE | Multiple Lines of Evidence |
| MLE | Model Law Engineer (National Council of Examiners certification for Engineering and Surveying) |
| MLE | Missile Launch Envelope |
| MLE | Microprocessor Language Editor |
| MLE | Multi-Line Entry |
| MLE | Ministry of Labour and Environment (Bangladesh) |
| MLE | Mission Level Evaluation |
| MLE | Militaire Luchtvaart Eis |
| MLE | Mid-Latitude Ecosystem |
| MLE | Maximum Loss Expectancy (insurance) |