| Acronym | Definition |
|---|
| HPL | High Pressure Laminate |
| HPL | Hamilton Public Library (Ontario, Canada) |
| HPL | Hewlett Packard Laboratories |
| HPL | Hedberg Public Library (Janesville, WI) |
| HPL | Hindustan Prefab Limited (India) |
| HPL | Human Placental Lactogen |
| HPL | Home Phone Lan |
| HPL | Hellmann Perishable Logistics (Doral, FL) |
| HPL | Henrietta Public Library (Rochester, NY) |
| HPL | Horizontal Protection Level |
| HPL | Huntsville Public Library (Huntsville, AL) |
| HPL | Horn Point Laboratory |
| HPL | Human Performance Laboratory |
| HPL | High Performance Lighting |
| HPL | Haverhill Public Library (Haverhill, MA) |
| HPL | Hospital Professional Liability (insurance) |
| HPL | Hyperlipidemia |
| HPL | High Performance Leadership (Toastmasters Program) |
| HPL | Halifax Public Library (Halifax, Canada) |
| HPL | High-Level Programming Language |
| HPL | Hiawatha Public Library (Hiawatha, IA) |
| HPL | Human Pancreatic Lipase |
| HPL | Heat Place (track) |
| HPL | Hillside Public Library (New York) |
| HPL | Howard Philip Lovecraft (writer) |
| HPL | Henderson Poverty Line (poverty index; Australia) |
| HPL | Hydroxyhemo Pyrrolin-2-One |
| HPL | Horizontal Protection Limit |
| HPL | Hackley Public Library (Muskegon, MI, USA) |
| HPL | High Priority List |
| HPL | Home-Phone LAN |
| HPL | High Performance Lane (bowling) |
| HPL | Hekemian Programming Language |
| HPL | Hotels Properties Limited |